Cyclopiazonic acid-induced changes in contractile activity of smooth muscle strips isolated from cat and guinea-pig stomach.

@article{Petkov1996CyclopiazonicAC,
  title={Cyclopiazonic acid-induced changes in contractile activity of smooth muscle strips isolated from cat and guinea-pig stomach.},
  author={Georgi V. Petkov and Kiril K. Boev},
  journal={European journal of pharmacology},
  year={1996},
  volume={318 1},
  pages={
          109-15
        }
}
  • G. Petkov, K. Boev
  • Published 27 December 1996
  • Chemistry, Biology, Medicine
  • European journal of pharmacology
The Role of a Ryanodine-Sensitive Ca2+-Store in the Regulation of Smooth Muscle Tone of the Cat Gastric Fundus
TLDR
Evidence is provided for the role of Ca 2+ release from a SR ryanodine-sensitive Ca2+ store in the maintenance of the muscle tone of the cat gastric fundus.
Corticotropin-releasing hormone acts on guinea pig ileal smooth muscle via protein kinase A
TLDR
It is suggested that CRH exerts its relaxing activity on ileal smooth muscle cells via PKA-dependent phosphorylation of some intracellular target coupled to sarcoplasmic reticulum Ca2+ storage machinery.
Mechanisms underlying the nitric oxide inhibitory effects in mouse ileal longitudinal muscle.
TLDR
It is suggested that NO causes inhibitory effects on longitudinal smooth muscle of mouse ileum through cGMP which in turn would activate the large conductance Ca2-dependent K+ channels, via localized ryanodine-sensitive Ca2+ release.
Capacitative calcium entry as a pulmonary specific vasoconstrictor mechanism in small muscular arteries of the rat
The effect of induction of capacitative Ca2+ entry (CCE) upon tone in small (i.d. 200–500 μm) intrapulmonary (IPA), mesenteric (MA), renal (RA), femoral (FA), and coronary arteries (CA) of the rat
Induction of heme oxygenase in guinea-pig stomach: roles in contraction and in single muscle cell ionic currents.
TLDR
This is the first study demonstrating that heme oxygenase is an inducible enzyme in guinea-pigs, which exerts a modulatory role on gastric smooth muscle excitability via carbon monoxide production.
The role of STIM1 and SOCE in smooth muscle contractility.
...
1
2
...

References

SHOWING 1-10 OF 23 REFERENCES
Cyclopiazonic acid is a sarcoplasmic reticulum Ca(2+)-pump inhibitor of rat aortic muscle.
  • H. Deng, C. Kwan
  • Biology, Medicine
    Zhongguo yao li xue bao = Acta pharmacologica Sinica
  • 1991
The effects of a mycotoxin, cyclopiazonic acid (CPA), on the contractile function of rat aortic smooth muscle rings were investigated to test the hypothesis that CPA selectively inhibits the
Effects of cyclopiazonic acid, a novel Ca2+‐ATPase inhibitor, on contractile responses in skinned ileal smooth muscle
TLDR
CPA appears to be a potent, reversible, and very specific inhibitor of the Ca2+‐pump in the storage sites of smooth muscle, and is an extremely valuable pharmacological tool.
Cyclopiazonic acid, an inhibitor of Ca2+‐ATPase in sarcoplasmic reticulum, increases excitability in ileal smooth muscle
TLDR
Results indicate that CPA enhances ileal smooth muscle excitability and increases Ca2-‐influx through voltage‐dependent Ca2+ channels and may be consistent with the hypothesis that C PA‐induced decrease in stored Ca due to Ca‐pump inhibition reduces the Ca2‐dependent K+ current and indirectly enhances Ca2–influxThrough membrane activity resulting from the increased excitability.
Effect of the Ca2+‐ATPase inhibitor, cyclopiazonic acid, on electromechanical coupling in the guinea‐pig ureter
TLDR
The effect of the sarcoplasmic reticulum (SR) Ca2+‐ATPase inhibitor, cyclopiazonic acid (CPA), on electromechanical coupling in the guinea‐pig ureter was investigated and the effect of CPA was reversed by washout.
Cyclopiazonic acid, an inhibitor of the sarcoplasmic reticulum Ca2+‐pump, reduces Ca2+‐dependent K+ currents in guinea‐pig smooth muscle cells
TLDR
The results indicate that IK‐Ca is selectively and strongly suppressed by CPA, a specific inhibitor of the Ca2+‐ATPase in sarcoplamic reticulum (SR), on membrane ionic currents examined in single smooth muscle cells freshly isolated from ileal longitudinal strips and urinary bladder of the guinea‐pig.
Effects of cyclopiazonic acid on phenylephrine‐induced contractions in the rabbit ear artery
TLDR
The findings indicate that the CPA‐induced rhythmic contractions in the endothelium‐denuded rabbit ear artery may be induced by the same ionic mechanism as endothelia‐regulated rhythmic responses, by which the K+ channel could regulate the probability of the Ca2+ channel being opened.
Cyclopiazonic acid is a specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulum.
TLDR
It is found that at low ATP concentrations (0.5-2 microM) the inhibition of ATPase activity was essentially complete at a CPA concentration of 6-8 nmol/mg protein, indicating stoichiometric reaction of CPA with the Ca2+-ATPase, which suggests that CPA interferes with the ATP-induced conformational changes related to Ca2- transport.
Cyclic GMP-induced activation of potassium currents by sarcoplasmic reticulum Ca2+ pump-dependent mechanism.
TLDR
The authors' data suggest that, in gastric fundus smooth muscles, NO-liberating substances and cGMP analogues contribute to the activation of a Ca2+ -release mechanism from the cell bulk, i.e. the myoplasm surrounding the contractile filaments, towards the plasma membrane, crossing the SR Ca2-stores.
Role of intracellular Ca2+ in EDRF release in rat aorta.
TLDR
The results indicate that CPA causes EDRF-release from endothelial cells and support the recent hypothesis that release of intracellular Ca from stores is the initiating factor in EDRf release, possibly allowing ongoing Ca entry to sustain release.
...
1
2
3
...