Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

@article{Chiang1996CyclopiaAD,
  title={Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function},
  author={Chin Chiang and Ying Litingtung and Eric J. Lee and Keith E. Young and Jeffrey L Corden and Heiner Westphal and Philip A. Beachy},
  journal={Nature},
  year={1996},
  volume={383},
  pages={407-413}
}
Targeted gene disruption in the mouse shows that the Sonic hedgehog(Shh) gene plays a critical role in patterning of vertebrate embryonic tissues, including the brain and spinal cord, the axial skeleton and the limbs. Early defects are observed in the establishment or maintenance of midline structures, such as the notochord and the floorplate, and later defects include absence of distal limb structures, cyclopia, absence of ventral cell types within the neural tube, and absence of the spinal… 
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TLDR
It is reported here that in wild-type embryos the floor plate develops as a simply organized single cell row, but that its development fails in embryos bearing the newly discovered zygotic lethal 'cyclops' mutation, cyc-1(b16).
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