Cyclophosphamide unmasks an antimetastatic effect of local tumor cryoablation.

  title={Cyclophosphamide unmasks an antimetastatic effect of local tumor cryoablation.},
  author={Moshe Yair Levy and Abhinav Sidana and Wasim H. Chowdhury and Steven B. Solomon and Charles G. Drake and Ronald Rodr{\'i}guez and Ephraim Joseph Fuchs},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={330 2},
Cryoablation of a solitary tumor mass releases intact tumor antigens and can induce protective antitumor immunity but has limited efficacy in the treatment of established metastatic cancer. Cyclophosphamide (Cy), an anticancer drug, selectively depletes regulatory T cells (T(reg)s) and attenuates suppression of antitumor immunity. We used a BALB/c mouse model of metastatic colon cancer to investigate the systemic antitumor effects of in situ cryotherapy alone or in combination with 200 mg/kg i… CONTINUE READING
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Regulatory T cells and cancer

  • HY Wang, RF Wang
  • Curr Opin Immunol
  • 2007
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