Cyclophosphamide uncovers two separate macrophage subpopulations with opposite immunogenic potential and different patterns of monokine production.

@article{Marcinkiewicz1994CyclophosphamideUT,
  title={Cyclophosphamide uncovers two separate macrophage subpopulations with opposite immunogenic potential and different patterns of monokine production.},
  author={Janusz Marcinkiewicz and Krysztof Bryniarski and Wlodzimierz Ptak},
  journal={Cytokine},
  year={1994},
  volume={6 5},
  pages={472-7}
}
As shown previously, thioglycollate-induced peritoneal macrophages consist of two subpopulations which differ morphologically and functionally. When tagged with trinitrophenyl hapten (TNP), one macrophage subpopulation induced in vivo effector cells (Th1) of contact sensitivity (CS) reaction, while the other induced suppressor T cells (Ts) which inhibit CS and are highly sensitive to the in vivo action of cyclophosphamide (CY). Our present experiments show that CY-resistant (Th inducers) and CY… CONTINUE READING

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