Cyclophosphamide triggers follicle activation and "burnout"; AS101 prevents follicle loss and preserves fertility.

@article{KalichPhilosoph2013CyclophosphamideTF,
  title={Cyclophosphamide triggers follicle activation and "burnout"; AS101 prevents follicle loss and preserves fertility.},
  author={Lital Kalich-Philosoph and Hadassa Roness and Alon Carmely and Michal Fishel-Bartal and Hagai Ligumsky and Shoshana Paglin and Ido Wolf and Hannah Kanety and Benjamin Sredni and Dror Meirow},
  journal={Science translational medicine},
  year={2013},
  volume={5 185},
  pages={185ra62}
}
Premature ovarian failure and infertility are major side effects of chemotherapy treatments in young cancer patients. A more thorough understanding of the mechanism behind chemotherapy-induced follicle loss is necessary to develop new methods to preserve fertility in these patients. We show that the alkylating agent cyclophosphamide (Cy) activates the growth of the quiescent primordial follicle population in mice, resulting in loss of ovarian reserve. Despite the initial massive apoptosis… CONTINUE READING