Cyclophosphamide treatment regulates the balance of functional/exhausted tumor-specific CD8+ T cells.

Abstract

An important question is how chemotherapy may (re-)activate tumor-specific immunity. In this study, we provide a phenotypic, functional and genomic analysis of tumor-specific CD8+ T cells in tumor (P815)-bearing mice, treated or not with cyclophosphamide. Our data show that chemotherapy favors the development of effector-type lymphocytes in tumor bed… (More)
DOI: 10.1080/2162402X.2017.1318234

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Cite this paper

@article{Hanoteau2017CyclophosphamideTR, title={Cyclophosphamide treatment regulates the balance of functional/exhausted tumor-specific CD8+ T cells.}, author={Aur{\'e}lie Hanoteau and Coralie Henin and David {\vS}vec and Charlotte Bisilliat Donnet and S{\'e}bastien Denanglaire and Didier Colau and Pedro Romero and Oberdan Leo and Benoit J Van den Eynde and Muriel Moser}, journal={Oncoimmunology}, year={2017}, volume={6 8}, pages={e1318234} }