Cyclophosphamide-induced cystitis in freely-moving conscious rats: behavioral approach to a new model of visceral pain.

@article{Boucher2000CyclophosphamideinducedCI,
  title={Cyclophosphamide-induced cystitis in freely-moving conscious rats: behavioral approach to a new model of visceral pain.},
  author={Michel Boucher and Murielle M{\'e}en and J P Codron and François Coudor{\'e} and Jean Louis K{\'e}m{\'e}ny and Alain Eschalier},
  journal={The Journal of urology},
  year={2000},
  volume={164 1},
  pages={203-8}
}
PURPOSE To develop a model of visceral pain in rats using a behavioral approach. Cyclophosphamide (CP), an antitumoral agent known to produce toxic effects on the bladder wall through its main toxic metabolite acrolein, was used to induce cystitis. MATERIALS AND METHODS CP was administered at doses of 50, 100 and 200 mg./kg. i.p. to male rats, and their… CONTINUE READING