Cyclophosphamide-induced changes in the MRL-lpr/lpr mouse: effects upon cellular composition, immune function, and disease.


MRL-lpr/lpr mice develop massive lymphadenopathy with excessive proliferation of T cells and associated immune abnormalities. To examine whether to not the disease process is intrinsic and irreversible, an immunomodulatory drug, cyclophosphamide, was administered to 16-week-old, sick MRL-lpr/lpr mice. Analysis of lymph node cells by flow cytometry from… (More)


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