Cyclophosphamide in the treatment of pemphigus vulgaris and bullous pemphigoid.

@article{Krain1972CyclophosphamideIT,
  title={Cyclophosphamide in the treatment of pemphigus vulgaris and bullous pemphigoid.},
  author={L. Krain and J. Landau and V. Newcomer},
  journal={Archives of dermatology},
  year={1972},
  volume={106 5},
  pages={
          657-61
        }
}
Cyclophosphamide has been used in the management of five patients with pemphigus vulgaris and two patients with bullous pemphigoid. All had developed serious side-effects from corticosteroid therapy, such as gastrointestinal bleeding, severe osteoporosis, diabetes mellitus, and depression. The use of cyclophosphamide made possible, in all patients, the reduction of the high maintenance level of corticosteroid therapy. The only side-effects encountered from therapy with cyclophosphamide were… Expand
Successful use of cyclophosphamide and prednisone for initial treatment of pemphigus vulgaris.
TLDR
Results indicate that initial combined program may be a highly effective treatment method for pemphigus vulgaris and followup from one to four years after treatment shows all five patients in remission; four require no medication. Expand
The treatment of bullous pemphigoid with tetracycline and niacinamide. A preliminary report.
Patients with moderate to severe bullous pemphigoid are usually treated with systemic corticosteroids. Four patients were treated with tetracycline hydrochloride and niacinamide because of theExpand
Cyclophosphamide plus vincristine and prednisone in the treatment of severe pemphigus vulgaris refractory to conventional therapy.
TLDR
Five patients with severe pemphigus vulgaris refractory to conventional therapy with azathioprine and corticosteroids were treated with cyclophosphamide, vincristine and prednisone, finding this association may be useful in controlling severe disease resistant to previous conventional therapies. Expand
TREATMENT OF PEMPHIGUS WITH CORTICOSTEROIDS AND CYCLOPHOSPHAMIDE
An initial combination of moderated doses of prednisone or prednisolone and cyclophosphamide seemed to be rapidly effective in controlling pemphigus vulgaris and pemphigus foliaceus with minimal sideExpand
The management of mucous membrane pemphigoid and pemphigus
TLDR
Treatment with these autoimmune blistering disorders should be individualized based on severity, extent, and rate of progression of disease, comorbidities, and age of the patient. Expand
Chronic herpes gestationis and antiphospholipid antibody syndrome successfully treated with cyclophosphamide.
TLDR
A patient with severe and persistent herpes gestationis in the postpartum period and the antiphospholipid antibody syndrome, both of which were refractory to high-dose corticosteroid therapy are described. Expand
The treatment of pemphigus and pemphigoid *
  • G. Levene
  • Medicine
  • Clinical and experimental dermatology
  • 1982
TLDR
Consideration is given to the use of three intravenous daily ‘bolus’ injections of high‐dose methyiprednisolone for the treatment of pemphigus, and to long acting tetraeosactrin (Synacthen Depot) injections with concurrent azathioprine for rapid control of bullous pEMphigoid in the elderly. Expand
Treatment of Bullous Pemphigoid
TLDR
New strategies for BP should include topical clobetasol propionate as the first line treatment and consider adjuvant therapy only in the very rare cases that are either resistant to or intolerant of this treatment. Expand
The adjuvant therapy of pemphigus. An update.
TLDR
Progress in the adjuvant therapy of pemphigus since the last review of this subject 10 years ago is summarized. Expand
Dexamethasone‐Cyclophosphamide Pulse Therapy in Pemphigus
TLDR
Fifty patients with pemphigus were treated with dexamethasone‐as one‐cyclophosphamide pulse therapy, the chief advantage being freedom from side effects of corticosteroid therapy. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 30 REFERENCES
Treatment of pemphigus vulgaris with methotrexate.
TLDR
Treatment with methotrexate was effective in three patients in whom the disease previously had been held in nearly complete remission by maintenance doses of prednisone, and its usefulness in one patient with very active pemphigus vulgaris was limited. Expand
Cyclophosphamide and pemphigus vulgaris.
TLDR
A 47-year-old man with pemphigus vulgaris complicated by diabetes mellitus, osteoporosis, and advanced steroid myopathy was treated with cyclophosphamide and has remained in remission for one year on a maintenance program. Expand
Studies in bullous diseases. Treatment of pemphigus vulgaris with immunosuppressives (steroids and methotrexate) and leucovorin calcium.
TLDR
Flexibility in administration of the use of methotrexate alone or in combination with steroids and leucovorin calcium is recommended in the treatment of pemphigus. Expand
Azathioprine in Treatment of Bullous Pemphigoid
Azathioprine was given to 11 patients with pemphigoid who had been on long-term maintenance therapy with prednisone or prednisolone. In nine of these prednisone therapy was withdrawn and all wereExpand
"Refractory" thrombocytopenic purpura treated successfully with cyclophosphamide.
TLDR
The experience indicates that cyclophosphamide can be a safe and effective means of inducing remission in patients refractory to conventional therapy. Expand
IMMUNOSUPPRESSANTS IN THE TREATMENT OF PEMPHIGUS
TLDR
The results are presented of parenteral treatment with methotrexate in 19 cases of various forms of pemphigus; small doses of corticosteroids were given in addition. Expand
Pemphigus vulgaris successfully treated with cyclophosphamide.
TLDR
A 49-year-old woman had pemphigus vulgaris for 8 years and was treated for 5 years with prednisolone in increasingly high doses, up to 200 mg daily, and had developed numerous and numerous side effects. Expand
Recent advances in the diagnosis and treatment of pemphigus.
TLDR
The immunofluorescent findings have in part stimulated the use of immunosuppressive agents in the management of pemphigus. Expand
Pemphigus. A 20-year survey of experience with 70 cases.
  • J. Ryan
  • Medicine
  • Archives of dermatology
  • 1971
In a 20-year survey of 70 cases of pemphigus at the Cleveland Clinic including results of treatment with corticosteroids and immunosuppressive agents, attention is drawn to complications and the highExpand
Urinary-bladder fibrosis and telangiectasia associated with long-term cyclophosphamide therapy.
TLDR
Adequate hydration of the patient and, when feasible, oral rather than intravenous administration of the drug may reduce urinary-bladder fibrosis associated with cyclophosphamide therapy. Expand
...
1
2
3
...