Cyclophosphamide cystitis in rats: involvement of capsaicin-sensitive primary afferents.

@article{Maggi1992CyclophosphamideCI,
  title={Cyclophosphamide cystitis in rats: involvement of capsaicin-sensitive primary afferents.},
  author={Carlo A. Maggi and Alessandro Lecci and Paolo Santicioli and Elena del Bianco and Sandro Giuliani},
  journal={Journal of the autonomic nervous system},
  year={1992},
  volume={38 3},
  pages={
          201-8
        }
}
The involvement of capsaicin-sensitive primary afferent neurons in cyclophosphamide (CYP)-induced cystitis has been investigated in rats. CYP (150 mg/kg) was administered 48 h before testing in both vehicle- and capsaicin- (50 mg/kg s.c., 4 days before) treated rats. Some experiments were also performed 96 h after bilateral removal of pelvic ganglia to produce bladder denervation. CYP administration produced a marked detrusor hyperreflexia which was abolished by capsaicin pretreatment… Expand
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  • Medicine
  • Journal of Chemical Neuroanatomy
  • 2001
TLDR
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