Cyclophosphamide and Lupus Nephritis: When, How, For How Long?

@article{Ntali2011CyclophosphamideAL,
  title={Cyclophosphamide and Lupus Nephritis: When, How, For How Long?},
  author={Stella Ntali and G. Bertsias and D. Boumpas},
  journal={Clinical Reviews in Allergy & Immunology},
  year={2011},
  volume={40},
  pages={181-191}
}
  • Stella Ntali, G. Bertsias, D. Boumpas
  • Published 2011
  • Medicine
  • Clinical Reviews in Allergy & Immunology
  • Ever since the introduction of cyclophosphamide (CY), the management of lupus nephritis has dramatically changed, and its prognosis has greatly improved. Based on randomized controlled trials and long-term observational studies, pulse therapy with CY in combination with methyl-prednisolone (MP) is the “gold standard” of therapy for severe lupus. The realization of the significant gonadal toxicity intensified the efforts for the development of alternative immunosuppressive agents. In a large… CONTINUE READING
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