Cyclophosphamide and Lupus Nephritis: When, How, For How Long?

@article{Ntali2011CyclophosphamideAL,
  title={Cyclophosphamide and Lupus Nephritis: When, How, For How Long?},
  author={Stella Ntali and George K. Bertsias and Dimitrios T Boumpas},
  journal={Clinical Reviews in Allergy \& Immunology},
  year={2011},
  volume={40},
  pages={181-191}
}
Ever since the introduction of cyclophosphamide (CY), the management of lupus nephritis has dramatically changed, and its prognosis has greatly improved. Based on randomized controlled trials and long-term observational studies, pulse therapy with CY in combination with methyl-prednisolone (MP) is the “gold standard” of therapy for severe lupus. The realization of the significant gonadal toxicity intensified the efforts for the development of alternative immunosuppressive agents. In a large… 

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