Cyclophosphamide, doxorubicin, vincristine, and prednisone for primary central nervous system lymphoma: short-duration response and multifocal intracerebral recurrence preceding radiotherapy.

@article{Lachance1994CyclophosphamideDV,
  title={Cyclophosphamide, doxorubicin, vincristine, and prednisone for primary central nervous system lymphoma: short-duration response and multifocal intracerebral recurrence preceding radiotherapy.},
  author={Daniel H. Lachance and David M. Brizel and Jon P. Gockerman and Edward Charles Halperin and Peter C. Burger and Orest B. Boyko and M. T. Brown and S. Clifford Schold},
  journal={Neurology},
  year={1994},
  volume={44 9},
  pages={1721-7}
}
The activity of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) in the treatment of primary central nervous system lymphoma (PCNSL) prior to radiotherapy was studied in six patients. Primary lesions were reduced by 80% or more on contrast-enhancing cross-sectional area in four patients and to a lesser extent in two others after two cycles of chemotherapy. The primary lesion sites demonstrated no contrast enhancement in the three patients who completed four cycles of therapy… CONTINUE READING

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PCNSL is highly responsive to standard systemic non - Hodgkin 's lymphoma chemotherapy regimens , but the pattern and rapidity of relapse suggest mechanisms of failure including inherent or rapidly evolving antineoplastic drug resistance and perhaps limited drug delivery to occult sites of disease in the brain .
The activity of cyclophosphamide , doxorubicin , vincristine , and prednisone ( CHOP ) in the treatment of primary central nervous system lymphoma ( PCNSL ) prior to radiotherapy was studied in six patients .
Cyclophosphamide , doxorubicin , vincristine , and prednisone for primary central nervous system lymphoma : short - duration response and multifocal intracerebral recurrence preceding radiotherapy .
Cyclophosphamide , doxorubicin , vincristine , and prednisone for primary central nervous system lymphoma : short - duration response and multifocal intracerebral recurrence preceding radiotherapy .
The activity of cyclophosphamide , doxorubicin , vincristine , and prednisone ( CHOP ) in the treatment of primary central nervous system lymphoma ( PCNSL ) prior to radiotherapy was studied in six patients .
PCNSL is highly responsive to standard systemic non - Hodgkin 's lymphoma chemotherapy regimens , but the pattern and rapidity of relapse suggest mechanisms of failure including inherent or rapidly evolving antineoplastic drug resistance and perhaps limited drug delivery to occult sites of disease in the brain .
PCNSL is highly responsive to standard systemic non - Hodgkin 's lymphoma chemotherapy regimens , but the pattern and rapidity of relapse suggest mechanisms of failure including inherent or rapidly evolving antineoplastic drug resistance and perhaps limited drug delivery to occult sites of disease in the brain .
PCNSL is highly responsive to standard systemic non - Hodgkin 's lymphoma chemotherapy regimens , but the pattern and rapidity of relapse suggest mechanisms of failure including inherent or rapidly evolving antineoplastic drug resistance and perhaps limited drug delivery to occult sites of disease in the brain .
PCNSL is highly responsive to standard systemic non - Hodgkin 's lymphoma chemotherapy regimens , but the pattern and rapidity of relapse suggest mechanisms of failure including inherent or rapidly evolving antineoplastic drug resistance and perhaps limited drug delivery to occult sites of disease in the brain .
The activity of cyclophosphamide , doxorubicin , vincristine , and prednisone ( CHOP ) in the treatment of primary central nervous system lymphoma ( PCNSL ) prior to radiotherapy was studied in six patients .
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