Cyclophilin inhibitors reduce phosphorylation of RNA-dependent protein kinase to restore expression of IFN-stimulated genes in HCV-infected cells.

@article{Daito2014CyclophilinIR,
  title={Cyclophilin inhibitors reduce phosphorylation of RNA-dependent protein kinase to restore expression of IFN-stimulated genes in HCV-infected cells.},
  author={Takuji Daito and Koichi Watashi and Ann E Sluder and Hirofumi Ohashi and Syo Nakajima and Katyna Borroto-Esoda and Takashi Fujita and Takaji Wakita},
  journal={Gastroenterology},
  year={2014},
  volume={147 2},
  pages={
          463-72
        }
}
BACKGROUND & AIMS Cyclophilin inhibitors are being developed for treatment of hepatitis C virus (HCV) infection. They are believed to inhibit the HCV replication complex. We investigated whether cyclophilin inhibitors interact with interferon (IFN) signaling in cultured cells infected with HCV. METHODS We used immunoblot assays to compare expression of IFN-stimulated genes (ISGs) and of components of IFN signaling in HCV-infected and uninfected cells. RESULTS Incubation with IFN alfa… Expand
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