Cyclophilin D gene ablation protects mice from ischemic renal injury.

@article{DevalarajaNarashimha2009CyclophilinDG,
  title={Cyclophilin D gene ablation protects mice from ischemic renal injury.},
  author={Kishor Devalaraja-Narashimha and Alicia M Diener and Babu J Padanilam},
  journal={American journal of physiology. Renal physiology},
  year={2009},
  volume={297 3},
  pages={
          F749-59
        }
}
Increased oxidative stress and intracellular calcium levels and mitochondrial overloading of calcium during ischemic renal injury (IRI) favor mitochondrial membrane permeability transition pore (MPTP) opening and subsequent necrotic cell death. Cyclophilin D (CypD) is an essential component of MPTP, and recent findings implicate its role in necrotic, but not apoptotic, cell death. To evaluate the role of CypD following IRI, we tested the hypothesis that CypD gene ablation protects mice from IRI… CONTINUE READING

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