Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice.

@article{Elrod2010CyclophilinDC,
  title={Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice.},
  author={John W. Elrod and Renee P Wong and Shikha Mishra and Ronald J. Vagnozzi and Bhuvana Sakthievel and Sanjeewa A. Goonasekera and Jason Karch and Scott Gabel and John L. Farber and Thomas L. Force and Joan Brown and Elizabeth Murphy and Jeffery D Molkentin},
  journal={The Journal of clinical investigation},
  year={2010},
  volume={120 10},
  pages={3680-7}
}
Cyclophilin D (which is encoded by the Ppif gene) is a mitochondrial matrix peptidyl-prolyl isomerase known to modulate opening of the mitochondrial permeability transition pore (MPTP). Apart from regulating necrotic cell death, the physiologic function of the MPTP is largely unknown. Here we have shown that Ppif(-/-) mice exhibit substantially greater cardiac hypertrophy, fibrosis, and reduction in myocardial function in response to pressure overload stimulation than control mice. In addition… CONTINUE READING
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