Cyclophilin D as a drug target.

  title={Cyclophilin D as a drug target.},
  author={Peter C. Waldmeier and Kaspar Zimmermann and Ting Qian and Marina Tintelnot-Blomley and John J. Lemasters},
  journal={Current medicinal chemistry},
  volume={10 16},
The mitochondrial permeability transition (MPT) plays an important role in damage-induced cell death, and agents inhibiting the MPT may have a therapeutic potential for treating human conditions such as ischemia/reperfusion injury, trauma, and neurodegenerative diseases. The mitochondrial matrix protein, cyclophilin D (CYP D), a member of a family of highly homologous peptidylprolyl cis-trans isomerases (PPIases), plays a decisive role in MPT, being an integral constituent of the MPT pore… CONTINUE READING


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