Cyclophilin B attenuates the expression of TNF-α in lipopolysaccharide-stimulated macrophages through the induction of B cell lymphoma-3.

@article{Marcant2012CyclophilinBA,
  title={Cyclophilin B attenuates the expression of TNF-α in lipopolysaccharide-stimulated macrophages through the induction of B cell lymphoma-3.},
  author={Adeline Marcant and Agn{\`e}s Denys and Aur{\'e}lie Melchior and Pierre Martinez and Audrey Deligny and Mathieu Carpentier and Fabrice Allain},
  journal={Journal of immunology},
  year={2012},
  volume={189 4},
  pages={2023-32}
}
Extracellular cyclophilin A (CyPA) and CyPB have been well described as chemotactic factors for various leukocyte subsets, suggesting their contribution to inflammatory responses. Unlike CyPA, CyPB accumulates in extracellular matrixes, from which it is released by inflammatory proteases. Hence, we hypothesized that it could participate in tissue inflammation by regulating the activity of macrophages. In the current study, we confirmed that CyPB initiated in vitro migration of macrophages, but… CONTINUE READING
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