Cyclophilin A levels dictate infection efficiency of human immunodeficiency virus type 1 capsid escape mutants A92E and G94D.

@article{Ylinen2009CyclophilinAL,
  title={Cyclophilin A levels dictate infection efficiency of human immunodeficiency virus type 1 capsid escape mutants A92E and G94D.},
  author={Laura M. J. Ylinen and Torsten Schaller and Amanda J. Price and Adam J. Fletcher and Mahdad Noursadeghi and Leo C James and Greg J. Towers},
  journal={Journal of virology},
  year={2009},
  volume={83 4},
  pages={2044-7}
}
Cyclophilin A (CypA) is an important human immunodeficiency virus type 1 (HIV-1) cofactor in human cells. HIV-1 A92E and G94D capsid escape mutants arise during CypA inhibition and in certain cell lines are dependent on CypA inhibition. Here we show that dependence on CypA inhibition is due to high CypA levels. Restricted HIV-1 is stable, and remarkably, restriction is augmented by arresting cell division. Nuclear entry is not inhibited. We propose that high CypA levels and capsid mutations… CONTINUE READING

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