Cyclophilin A is a proinflammatory cytokine that activates endothelial cells.

  title={Cyclophilin A is a proinflammatory cytokine that activates endothelial cells.},
  author={Zheng Gen Jin and Andreea O. Lungu and Liang Xie and Meng Wang and Chelsea C Wong and Bradford C. Berk},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={24 7},
OBJECTIVE Cyclophilin A (CyPA) is an abundant intracellular protein that is considered to be the main target of the immunosuppressive drug cyclosporine A. We and others showed that CyPA is secreted from smooth muscle cells and macrophages in response to oxidative stress and lipopolysaccharide, suggesting a role for CyPA in inflammation. We therefore studied the proinflammatory effects of CyPA on vascular endothelium. METHODS AND RESULTS Because atherosclerosis is an inflammatory disease, we… CONTINUE READING


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Signal Transduction Cascades Responsive to Oxidative Stress in the Vasculature

  • ZG Jin, BC Berk
  • Protein Adaption and Signal Transduction
  • 2001

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