Cyclophilin A enhances macrophage differentiation and lipid uptake in high glucose conditions: a cellular mechanism for accelerated macro vascular disease in diabetes mellitus

@inproceedings{Ramachandran2016CyclophilinAE,
  title={Cyclophilin A enhances macrophage differentiation and lipid uptake in high glucose conditions: a cellular mechanism for accelerated macro vascular disease in diabetes mellitus},
  author={Surya Ramachandran and Anandan Vinitha and Cheranellore Chandrasekharan Kartha},
  booktitle={Cardiovascular diabetology},
  year={2016}
}
BACKGROUND Vascular disease in diabetes is initiated by monocyte adhesion to vascular endothelium, transmigration and formation of foam cells. Increasing clinical evidence supports a role for the secretory protein, cyclophilin A in diabetic vascular disease. The means by which cyclophilin A contributes to vascular lesion development in diabetes is however largely unknown. METHODS In this study we investigated using THP1 cells and human monocytes whether cyclophilin A under hyperglycemic… CONTINUE READING
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Proteomic profiling of high glucose primed monocytes identifies cyclophilin A as a potential secretory marker of inflammation in type 2 diabetes

  • S Ramachandran, A Venugopal, +4 authors C. Kartha
  • Proteomics
  • 2012
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