Cyclophilin A differentially activates monocytes and endothelial cells: role of purity, activity, and endotoxin contamination in commercial preparations.

@article{Payeli2008CyclophilinAD,
  title={Cyclophilin A differentially activates monocytes and endothelial cells: role of purity, activity, and endotoxin contamination in commercial preparations.},
  author={Sravan K Payeli and Cordelia Schiene-Fischer and Jan Steffel and Giovanni G Camici and Izabela Rozenberg and Thomas Felix L{\"u}scher and Felix C. Tanner},
  journal={Atherosclerosis},
  year={2008},
  volume={197 2},
  pages={564-71}
}
BACKGROUND Cyclophilin A (CyPA) is a cytoplasmic protein secreted under inflammatory conditions. Extracellular CyPA is detected in atherosclerotic plaques and has been observed to activate endothelial cells as well as monocytes. METHODS AND RESULTS Commercially available recombinant CyPA-induced expression of tissue factor (TF) and vascular cell adhesion molecule-1 (VCAM-1) in human aortic endothelial cells (HAEC). However, CyPA from commercial sources contained lipopolysaccharide at… CONTINUE READING

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