Cyclophilin A: a key player for human disease

  title={Cyclophilin A: a key player for human disease},
  author={Peter J. Nigro and Giulio Pompilio and Maurizio Colognesi Capogrossi},
  booktitle={Cell Death and Disease},
Cyclophilin A (CyPA) is a ubiquitously distributed protein belonging to the immunophilin family. CyPA has peptidyl prolyl cis-trans isomerase (PPIase) activity, which regulates protein folding and trafficking. Although CyPA was initially believed to function primarily as an intracellular protein, recent studies have revealed that it can be secreted by cells in response to inflammatory stimuli. Current research in animal models and humans has provided compelling evidences supporting the critical… CONTINUE READING
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