Cyclopeptides containing the DEKS motif as conformationally restricted collagen telopeptide analogues: synthesis and conformational analysis.

@article{Wodtke2015CyclopeptidesCT,
  title={Cyclopeptides containing the DEKS motif as conformationally restricted collagen telopeptide analogues: synthesis and conformational analysis.},
  author={Robert Wodtke and Gloria Ruiz-G{\'o}mez and Manuela Kuchar and M. Teresa Pisabarro and Pavl{\'i}na Novotn{\'a} and Marie Urbanov{\'a} and J{\"o}rg Steinbach and Jens Pietzsch and Reik L{\"o}ser},
  journal={Organic & biomolecular chemistry},
  year={2015},
  volume={13 6},
  pages={1878-96}
}
The collagen telopeptides play an important role for lysyl oxidase-mediated crosslinking, a process which is deregulated during tumour progression. The DEKS motif which is located within the N-terminal telopeptide of the α1 chain of type I collagen has been suggested to adopt a βI-turn conformation upon docking to its triple-helical receptor domain, which seems to be critical for lysyl oxidase-catalysed deamination and subsequent crosslinking by Schiff-base formation. Herein, the design and… CONTINUE READING

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