Cyclopentyl-pyrimidine based analogues as novel and potent IGF-1R inhibitor.


A series of novel 2-amino-4-pyrazolecyclopentylpyrimidines have been prepared and evaluated as IGF-1R tyrosin kinase inhibitors. The in vitro activity was found to depend strongly on the substitution pattern in the 2- amino ring, 4-pyrazolo moieties and size of fused saturated ring with the central pyrimidine core. A stepwise optimization by combination of… (More)
DOI: 10.1016/j.ejmech.2014.12.053


Cite this paper

@article{Aware2015CyclopentylpyrimidineBA, title={Cyclopentyl-pyrimidine based analogues as novel and potent IGF-1R inhibitor.}, author={Valmik Aware and Nitin Gaikwad and Sambhaji Chavan and Sonal M Manohar and Julie Bose and Smriti Khanna and Chandrika B-Rao and Neeta Dixit and Kishori Sharan Singh and Anagha A. Damre and Rajiv Kumar Sharma and Sambhaji V Patil and Abhijit Roychowdhury}, journal={European journal of medicinal chemistry}, year={2015}, volume={92}, pages={246-56} }