Cyclopentenyl cytosine increases the phosphorylation and incorporation into DNA of 1-beta-D-arabinofuranosyl cytosine in a human T-lymphoblastic cell line.

@article{Verschuur2002CyclopentenylCI,
  title={Cyclopentenyl cytosine increases the phosphorylation and incorporation into DNA of 1-beta-D-arabinofuranosyl cytosine in a human T-lymphoblastic cell line.},
  author={Arnauld C. Verschuur and Albert H van Gennip and Ren{\'e} Leen and Paul Antoine Vo{\^u}te and Josanne Brinkman and Andr{\'e} B P van Kuilenburg},
  journal={International journal of cancer},
  year={2002},
  volume={98 4},
  pages={616-23}
}
The cytotoxic effect of 1-beta-D-arabinofuranosyl cytosine (araC) depends on the intracellular phosphorylation into its active compound araCTP, on the degree of degradation of araCTP and on the incorporation of araCTP into DNA. Deoxycytidine triphosphate (dCTP) inhibits the phosphorylation of araC (by feedback inhibition of the enzyme deoxycytidine kinase) and the incorporation of araCTP into DNA (by competition for DNA polymerase). In a T-lymphoblastic cell line, we studied whether the… CONTINUE READING
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