Cyclopentenone prostaglandins of the J series inhibit the ubiquitin isopeptidase activity of the proteasome pathway.

@article{Mullally2001CyclopentenonePO,
  title={Cyclopentenone prostaglandins of the J series inhibit the ubiquitin isopeptidase activity of the proteasome pathway.},
  author={James E Mullally and Philip J. Moos and Kornelia Edes and Frank A. Fitzpatrick},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 32},
  pages={30366-73}
}
Electrophilic eicosanoids of the J series, with their distinctive cross-conjugated alpha,beta-unsaturated ketone, inactivate genetically wild type tumor suppressor p53 in a manner analogous to prostaglandins of the A series. Like the prostaglandins of the A series, prostaglandins of the J series have a structural determinant (endocyclic cyclopentenone) that… CONTINUE READING