Cyclopamine reverts acquired chemoresistance and down-regulates cancer stem cell markers in pancreatic cancer cell lines.

@article{Yao2011CyclopamineRA,
  title={Cyclopamine reverts acquired chemoresistance and down-regulates cancer stem cell markers in pancreatic cancer cell lines.},
  author={Jie Yao and Yong Ho An and Ji-shu Wie and Zhen-ling Ji and Zi-peng Lu and Jun-li Wu and Kuirong Jiang and Ping Chen and Zekuan Xu and Yi Miao},
  journal={Swiss medical weekly},
  year={2011},
  volume={141},
  pages={
          w13208
        }
}
BACKGROUND The hedgehog (Hh) pathway has been implicated in the pathogenesis of cancer including pancreatic ductal adenocarcinoma (PDAC). Recent studies have suggested that Hh plays an important role in maintaining the cancer stem cell (CSCs) pool. Gemcitabine-resistant pancreatic cancer cells highly express some of the CSCs markers. However, the expression level of Hh members in gemcitabine-resistant pancreatic cancer cells remains unknown. The aim of this study was to verify the expression of… CONTINUE READING

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