Cyclooxygenases 1 and 2.

  title={Cyclooxygenases 1 and 2.},
  author={John R. Vane and Yeshwant S. Bakhle and R. M. Botting},
  journal={Annual review of pharmacology and toxicology},
Cyclooxygenase (COX), first purified in 1976 and cloned in 1988, is the key enzyme in the synthesis of prostaglandins (PGs) from arachidonic acid. In 1991, several laboratories identified a product from a second gene with COX activity and called it COX-2. However, COX-2 was inducible, and the inducing stimuli included pro-inflammatory cytokines and growth factors, implying a role for COX-2 in both inflammation and control of cell growth. The two isoforms of COX are almost identical in structure… CONTINUE READING
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