Cyclooxygenases: structural, cellular, and molecular biology.

  title={Cyclooxygenases: structural, cellular, and molecular biology.},
  author={William Leo Smith and David L Dewitt and R. Michael Garavito},
  journal={Annual review of biochemistry},
The prostaglandin endoperoxide H synthases-1 and 2 (PGHS-1 and PGHS-2; also cyclooxygenases-1 and 2, COX-1 and COX-2) catalyze the committed step in prostaglandin synthesis. PGHS-1 and 2 are of particular interest because they are the major targets of nonsteroidal anti-inflammatory drugs (NSAIDs) including aspirin, ibuprofen, and the new COX-2 inhibitors. Inhibition of the PGHSs with NSAIDs acutely reduces inflammation, pain, and fever, and long-term use of these drugs reduces fatal thrombotic… CONTINUE READING
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