Cyclooxygenase isozymes involved in adaptive functional responses in rat stomach after barrier disruption.

@article{Takeeda2003CyclooxygenaseII,
  title={Cyclooxygenase isozymes involved in adaptive functional responses in rat stomach after barrier disruption.},
  author={Masanori Takeeda and Masanori Yamato and Shinichi Kato and Koji Takeuchi},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2003},
  volume={307 2},
  pages={
          713-9
        }
}
  • Masanori Takeeda, Masanori Yamato, +1 author Koji Takeuchi
  • Published in
    The Journal of pharmacology…
    2003
  • Chemistry, Medicine
  • We investigated the preferential role of cyclooxygenase (COX) isozymes in various functional changes of the rat stomach after exposure to taurocholate (TC) as a mild irritant. Under urethane anesthesia, a rat stomach mounted in an ex vivo chamber was perfused with saline or acid (50 mM HCl), and transmucosal potential difference (PD), gastric mucosal blood flow (GMBF), and acid secretion were measured before and after exposure of the stomach to 20 mM TC for 30 min. Indomethacin, 5-(4… CONTINUE READING

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