Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition.

  title={Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition.},
  author={Daniel L. Simmons and R. M. Botting and Timothy Hla},
  journal={Pharmacological reviews},
  volume={56 3},
Nonsteroidal anti-inflammatory drugs (NSAIDs) represent one of the most highly utilized classes of pharmaceutical agents in medicine. All NSAIDs act through inhibiting prostaglandin synthesis, a catalytic activity possessed by two distinct cyclooxygenase (COX) isozymes encoded by separate genes. The discovery of COX-2 launched a new era in NSAID pharmacology, resulting in the synthesis, marketing, and widespread use of COX-2 selective drugs. These pharmaceutical agents have quickly become… CONTINUE READING
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