Cyclooxygenase is regulated by ET-1 and MAPKs in peripheral lung microvascular smooth muscle cells.

@article{Chen2003CyclooxygenaseIR,
  title={Cyclooxygenase is regulated by ET-1 and MAPKs in peripheral lung microvascular smooth muscle cells.},
  author={Daohong Chen and Elena V Balyakina and Mayme Lee Lawrence and Brian W. Christman and Barbara O. Meyrick},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2003},
  volume={284 4},
  pages={L614-21}
}
We examined the hypothesis that the potent vasoconstrictor endothelin (ET)-1 regulates both its own production and production of the vasodilator prostaglandins PGE(2) and prostacyclin in sheep peripheral lung vascular smooth muscle cells (PLVSMC). Confluent layers of PLVSMC were exposed to 10 nM ET-1; expression of the prepro (pp)-ET-1, cyclooxygenase (COX)-1, and COX-2 genes was examined by RT-PCR and Western analysis. Intracellular levels of ET-1 were measured by ELISA with and without… CONTINUE READING

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