Cyclooxygenase inhibition augments central blood pressure and aortic wave reflection in aging humans.

@article{Barnes2012CyclooxygenaseIA,
  title={Cyclooxygenase inhibition augments central blood pressure and aortic wave reflection in aging humans.},
  author={Jill N Barnes and Darren P Casey and Casey N. Hines and Wayne T Nicholson and Michael J. Joyner},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2012},
  volume={302 12},
  pages={H2629-34}
}
The augmentation index and central blood pressure increase with normal aging. Recently, cyclooxygenase (COX) inhibitors, commonly used for the treatment of pain, have been associated with transient increases in the risk of cardiovascular events. We examined the effects of the COX inhibitor indomethacin (Indo) on central arterial hemodynamics and wave reflection characteristics in young and old healthy adults. High-fidelity radial arterial pressure waveforms were measured noninvasively by… CONTINUE READING
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