Cyclooxygenase in biology and disease
@article{DuBois1998CyclooxygenaseIB, title={Cyclooxygenase in biology and disease}, author={Raymond N. DuBois and Steven B Abramson and Leslie J. Crofford and Rajnish A. Gupta and Lee S Simon and L. B. A. van der Putte and Peter E. Lipsky}, journal={The FASEB Journal}, year={1998}, volume={12}, pages={1063 - 1073} }
Cyclooxygenase (COX), the key enzyme required for the conversion of arachidonic acid to prostaglandins was first identified over 20 years ago. Drugs, like aspirin, that inhibit cyclooxygenase activity have been available to the public for about 100 years. In the past decade, however, more progress has been made in understanding the role of cyclooxygenase enzymes in biology and disease than at any other time in history. Two cyclooxygenase isoforms have been identified and are referred to as COX…
2,504 Citations
Cyclooxygenase and prostaglandin synthases in atherosclerosis: recent insights and future perspectives.
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Cyclooxygenase-2 : Pathway form anti-inflammatory to Anti-cancer drugs
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The biology as well as the role of these COX isoenzymes in various prevalent pathophysiological conditions and the revolution in biology over the past two decades has resulted in radically new approaches and opportunities for drug discovery are discussed.
A Pharmacological Review on Cyclooxygenase Enzyme
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The activity of cyclo-oxygenase-1 and 2 results in the production of a variety of potent biological mediators (the prostaglandins) that regulate homeostatic and disease processes.
Recommendations for the clinical use of cyclooxygenase-2-specific inhibitors.
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The American journal of medicine
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Novel compounds that are selective for this isozyme, the so-called selective COX-2 inhibitors or COXIBs, which retain anti-inflammatory activity but minimize the risk of gastrointestinal toxicity and bleeding, have been developed.
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The best-known targets of NSAIDs are the Cox enzymes, and Cox-2 (but not Cox-1) is elevated in gastrointestinal carcinomas, and this review focuses on the role of Cox- 2 in carcinogenesis of the gastrointestinal tract.
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Biology
Best practice & research. Clinical gastroenterology
The goal of this chapter is to provide a review of the role of cyclo-oxygenase in biology and disease, and to summarize the current understanding of mechanisms for the regulation of COX-2 expression.
Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition
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Characterization of the two COX isozymes is allowing the discrimination of the roles each play in physiological processes such as homeostatic maintenance of the gastrointestinal tract, renal function, blood clotting, embryonic implantation, parturition, pain, and fever.
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Medicine, Biology
Recent efforts to identify the molecular mechanisms by which COX-2-derived prostanoids exert their proneoplastic effects have provided a rationale for the possible use of non-steroidal anti-inflammatory drugs alone or in combination with conventional or experimental anticancer agents for the treatment or prevention of gastrointestinal cancers.
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