Cyclooxygenase as a target for colorectal cancer chemoprevention.

  title={Cyclooxygenase as a target for colorectal cancer chemoprevention.},
  author={Let{\'i}cia Moreira and Antoni Castells},
  journal={Current drug targets},
  volume={12 13},
Colorectal cancer (CRC) is one of the most common neoplasia in Western countries and the second leading cause of cancer-related death. The vast majority of cases belong to sporadic forms, whereas a small but relevant proportion of them corresponds to inherited disorders, i.e. familial adenomatous polyposis and Lynch syndrome. These individuals with germline mutations in cancer-promoting genes, along with those who had already developed a colorectal neoplasm, either adenoma or carcinoma, stand… CONTINUE READING
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