Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells

  title={Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells},
  author={Masahiko Tsujii and Sunao Kawano and Shingo Tsuji and Hitoshi Sawaoka and Masatsugu Hori and Raymond N. Dubois},
To explore the role of cyclooxygenase (COX) in endothelial cell migration and angiogenesis, we have used two in vitro model systems involving coculture of endothelial cells with colon carcinoma cells. COX-2-overexpressing cells produce prostaglandins, proangiogenic factors, and stimulate both endothelial migration and tube formation, while control cells have little activity. The effect is inhibited by antibodies to combinations of angiogenic factors, by NS-398 (a selective COX-2 inhibitor), and… CONTINUE READING