Cyclooxygenase-2 selective inhibitor prevents implantation of eutopic endometrium to ectopic sites in rats.

@article{Matsuzaki2004Cyclooxygenase2SI,
  title={Cyclooxygenase-2 selective inhibitor prevents implantation of eutopic endometrium to ectopic sites in rats.},
  author={Sachiko Matsuzaki and Michel Canis and Claude Darcha and Radhouane Dallel and Kunihiro Okamura and G{\'e}rard Mage},
  journal={Fertility and sterility},
  year={2004},
  volume={82 6},
  pages={1609-15}
}
OBJECTIVE To evaluate Cox-2 inhibition on surgically induced endometriosis in rats. DESIGN Prospective, randomized study SETTING Academic facility. ANIMAL(S) Seventy adult female Sprague-Dawley rats. INTERVENTION(S) Uterine fragments were implanted into abdominal peritoneum with suture (site A), and/or into the pelvic cavity without suture (site B). Oral gavage of Cox-2 inhibitor (5 mg/kg/day, twice/day) was started 4 weeks postimplantation (protocol-1), after implantation (protocol-2… CONTINUE READING