Cyclooxygenase 2-selective and nonselective nonsteroidal anti-inflammatory drugs induce oxidative stress by up-regulating vascular NADPH oxidases.

@article{Li2008Cyclooxygenase2A,
  title={Cyclooxygenase 2-selective and nonselective nonsteroidal anti-inflammatory drugs induce oxidative stress by up-regulating vascular NADPH oxidases.},
  author={Huige Li and Marcus Hortmann and Andreas Daiber and Matthias Oelze and Mir Abolfazl Ostad and Petra M. Schwarz and Hui Xu and Nengxing Xia and Andrei L. Kleschyov and Christian Mang and Ascan Warnholtz and Th. M{\"u}nzel and Ulrich F{\"o}rstermann},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2008},
  volume={326 3},
  pages={
          745-53
        }
}
Cyclooxygenase 2-selective inhibitors (coxibs) and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with an increase in cardiovascular events. The current study was designed to test the effect of coxibs and nonselective NSAIDs on vascular superoxide and nitric oxide (NO) production. mRNA expression of endothelial NO synthase (eNOS) and of the vascular NADPH oxidases was studied in spontaneously hypertensive rats (SHR) and in human endothelial cells. The expression of… CONTINUE READING

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