Cyclooxygenase-2 regulation in colon cancer cells: modulation of RNA polymerase II elongation by histone deacetylase inhibitors.

@article{Tong2005Cyclooxygenase2RI,
  title={Cyclooxygenase-2 regulation in colon cancer cells: modulation of RNA polymerase II elongation by histone deacetylase inhibitors.},
  author={Xin Tong and Lei Yin and Shree Joshi and Daniel W Rosenberg and Charles Giardina},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 16},
  pages={15503-9}
}
We are interested in the mechanism of cyclooxygenase-2 (Cox-2) regulation in colon cancer cells because this knowledge could provide insight into colon carcinogenesis and suggest ways to suppress Cox-2 expression in colon tumors. Studying the HT-29 colon cancer cell line as a model, we found that Cox-2 mRNA and protein levels were activated over 10-fold by the inflammatory cytokine tumor necrosis factor (TNF)-alpha. Moreover, we found that the histone deacetylase inhibitors butyrate and… CONTINUE READING
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