Cyclooxygenase-2-regulated vascular endothelial growth factor release in gastric fibroblasts.

  title={Cyclooxygenase-2-regulated vascular endothelial growth factor release in gastric fibroblasts.},
  author={Shuhei Miura and Atsushi Tatsuguchi and Ken Wada and Hiroki Takeyama and Yoko Shinji and Tetsuro Hiratsuka and Seiji Futagami and Kazumasa Miyake and Katya Gudis and Yuji Mizokami and Takeshi Matsuoka and Choitsu Sakamoto},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={287 2},
VEGF is a highly specific stimulator of endothelial cells and may play an important role in angiogenesis in the process of tissue regeneration. We previously showed that cyclooxygenase-2 (COX-2) expressed in mesenchymal cells of the ulcer bed is involved in the ulcer repair process. To clarify the role of COX-2 in angiogenesis during gastric ulcer healing, we investigated the relation between COX-2 expression and VEGF production in human gastric fibroblasts in vivo and in vitro. Gastric… CONTINUE READING
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Hepatocyte growth factor is the most potent endogenous stimulant of rabbit gastric G450 COX-2 REGULATES VEGF RELEASE BY GASTRIC FIBROBLASTS AJP-Gastrointest Liver Physiol

  • M Takahashi, S Ota, +7 authors T. Nakamura
  • J Clin Invest
  • 2004
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