Cyclooxygenase-2 promotes tumor growth and suppresses tumor immunity

@inproceedings{Liu2015Cyclooxygenase2PT,
  title={Cyclooxygenase-2 promotes tumor growth and suppresses tumor immunity},
  author={Bing Liu and Liyan Qu and S Yan},
  booktitle={Cancer Cell International},
  year={2015}
}
Cyclooxygenase-2 (COX-2), an inducible form of the enzyme that catalyzes the first step in the synthesis of prostanoids, is associated with inflammatory diseases and carcinogenesis, which is suspected to promote angiogenesis and tissue invasion of tumors and resistance to apoptosis. Meanwhile, COX-2 contributes to immune evasion and resistance to cancer immunotherapy, which plays a crucial role in the innate and adaptive immune response. The activity of COX-2-PGE2-EP signal pathway can suppress… CONTINUE READING
Highly Cited
This paper has 660 citations. REVIEW CITATIONS
Recent Discussions
This paper has been referenced on Twitter 6 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

661 Citations

0200400201620172018
Citations per Year
Semantic Scholar estimates that this publication has 661 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 50 references

Similar Papers

Loading similar papers…