Cyclooxygenase-2 mediates hydrogen peroxide-induced wound repair in human endothelial cells.

@article{Eligini2009Cyclooxygenase2MH,
  title={Cyclooxygenase-2 mediates hydrogen peroxide-induced wound repair in human endothelial cells.},
  author={Sonia Eligini and Izask{\'u}n Arenaz and Silvia Stella Barbieri and Maurizio L Faleri and Mauro Crisci and Elena Tremoli and Susanna Colli},
  journal={Free radical biology & medicine},
  year={2009},
  volume={46 10},
  pages={1428-36}
}
Cyclooxygenase-2 (Cox-2) metabolites produced by endothelial cells, particularly prostacyclin and prostaglandin E(2), profoundly affect vascular tone, regional blood flow, and angiogenesis. We have previously shown that reactive oxygen species induce Cox-2 expression in human endothelial cells (HUVEC), either on their own or as components of the signaling pathway triggered by TNFalpha, the prototypical inflammatory cytokine. Here we investigated the role of Cox-2 induced by hydrogen peroxide (H… CONTINUE READING