Cyclooxygenase-2 mediates anandamide metabolism in the mouse brain.

  title={Cyclooxygenase-2 mediates anandamide metabolism in the mouse brain.},
  author={Sherrye T. Glaser and Martin Kaczocha},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={335 2},
Cyclooxygenase-2 (COX-2) mediates inflammation and contributes to neurodegeneration. Best known for its pathological up-regulation, COX-2 is also constitutively expressed within the brain and mediates synaptic transmission through prostaglandin synthesis. Along with arachidonic acid, COX-2 oxygenates the endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol in vitro. Inhibition of COX-2 enhances retrograde signaling in the hippocampus, suggesting COX-2 mediates endocannabinoid tone in… CONTINUE READING