Cyclooxygenase-2 mRNA is up-regulated in cirrhotic or chronic hepatitis liver adjacent to hepatocellular carcinoma.

@article{Morinaga2002Cyclooxygenase2MI,
  title={Cyclooxygenase-2 mRNA is up-regulated in cirrhotic or chronic hepatitis liver adjacent to hepatocellular carcinoma.},
  author={Soichiro Morinaga and Yuji Yamamoto and Yoshikazu Noguchi and Toshio Imada and Yasushi Rino and Makoto Akaike and Yukio Sugimasa and Shoji Takemiya and Yoichi Kameda and Yoshinori Takanashi},
  journal={Journal of gastroenterology and hepatology},
  year={2002},
  volume={17 10},
  pages={
          1110-6
        }
}
BACKGROUND AND AIM Hepatocellular carcinoma (HCC) is unique in that its carcinogenesis is related to inflammatory changes and regenerative activities in the background liver. Although there are some data on cyclooxygenase (COX)-2 expression in HCC by immunohistochemical studies, little is known about the possible role of COX-2 in inducing hepatitis and/or carcinoma. To elucidate whether COX-2 is involved in a part of these processes, we attempted to examine COX-2 mRNA both in the adjacent non… CONTINUE READING

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