Cyclooxygenase 2 is up-regulated and localized to macrophages in the intestine of Min mice

@inproceedings{Hull1999Cyclooxygenase2I,
  title={Cyclooxygenase 2 is up-regulated and localized to macrophages in the intestine of Min mice},
  author={Mark A Hull and Jennifer K Booth and A Tisbury and Nigel Scott and Constanze Bonifer and Phil Markham and Patricia Louise Coletta},
  booktitle={British Journal of Cancer},
  year={1999}
}
SummaryExpression of cyclooxygenase 2 (COX-2) is believed to play an important role in adenoma formation in murine polyposis models, and inhibition of COX-2 activity may, at least, partly explain the chemopreventative activity of non-steroidal anti-inflammatory drugs against colorectal cancer in humans. However, the mechanism by which COX-2 acts in intestinal tumorigenesis remains unresolved because of conflicting data on the cellular localization of COX-2 in intestinal mucosa. Using… CONTINUE READING