Cyclooxygenase-2 is induced in the endothelial cells throughout the central nervous system during carrageenan-induced hind paw inflammation; its possible role in hyperalgesia.

@article{Ibuki2003Cyclooxygenase2II,
  title={Cyclooxygenase-2 is induced in the endothelial cells throughout the central nervous system during carrageenan-induced hind paw inflammation; its possible role in hyperalgesia.},
  author={Takae Ibuki and Kiyoshi Matsumura and Yasuo Yamazaki and Taiki Nozaki and Yoshifumi Tanaka and Shigeo Kobayashi},
  journal={Journal of neurochemistry},
  year={2003},
  volume={86 2},
  pages={318-28}
}
Inflammation is often accompanied with hyperalgesia. This hyperalgesia is mediated partly by prostaglandin(s) produced in the CNS through the cyclooxygenase-2 (COX-2) dependent pathway. However, it remains unclear where COX-2 is induced in the CNS during inflammation, and how it is involved in hyperalgesia. We studied the precise site of COX-2 induction in the CNS, the relation between the time course of COX-2 induction and that of hyperalgesia, and the effect of COX-2-selective inhibitor by… CONTINUE READING

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