Cyclooxygenase-2 is highly expressed in carcinoma in situ and T1 transitional cell carcinoma of the bladder.

@article{Shariat2003Cyclooxygenase2IH,
  title={Cyclooxygenase-2 is highly expressed in carcinoma in situ and T1 transitional cell carcinoma of the bladder.},
  author={Shahrokh F Shariat and Ja-Hong Kim and Gustavo Ayala and Kimberly A. Kho and Thomas M. Wheeler and Seth P. Lerner},
  journal={The Journal of urology},
  year={2003},
  volume={169 3},
  pages={938-42}
}
PURPOSE We describe cyclooxygenase-2 (COX-2) expression patterns in patients with carcinoma in situ and/or stage T1 transitional cell carcinoma. We determined whether expression is associated with clinical outcome in these patients. MATERIALS AND METHODS Immunostaining for COX-2 was performed on paraffin embedded bladder biopsy specimens from 2 independent groups of patients without muscle invasive carcinoma, including 39 with carcinoma in situ and 34 with stage T1 tumors. Immunoreactivity… CONTINUE READING
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