Cyclooxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis.

@article{Kuwano2004Cyclooxygenase2I,
  title={Cyclooxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis.},
  author={Takashi Kuwano and Shintaro Nakao and Hidetaka Yamamoto and Masazumi Tsuneyoshi and Tomoya Yamamoto and Michihiko Kuwano and Mayumi Ono},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2004},
  volume={18 2},
  pages={300-10}
}
Cyclooxygenase1 (COX1) and COX2 mediate the rate-limiting step in arachidonic acid metabolism. Expression of COX2 mRNA and protein is often enhanced in various human cell types by inflammatory cytokines such as interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNFalpha). IL-1beta enhanced expression of various prostanoids and this expression was blocked by COX2 selective inhibitors. IL-1beta markedly induced angiogenesis in vitro and in vivo, which was significantly inhibited by… CONTINUE READING
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