Cyclooxygenase 2 inhibitors: discovery, selectivity and the future.

  title={Cyclooxygenase 2 inhibitors: discovery, selectivity and the future.},
  author={Lawrence J Marnett and Amit S Kalgutkar},
  journal={Trends in pharmacological sciences},
  volume={20 11},
The recent marketing of two selective cyclooxygenase 2 (COX-2) inhibitors climaxes the first phase of an exciting and fast-paced effort to exploit a novel molecular target for nonsteroidal anti-inflammatory drugs (NSAIDs). Much has been written in the lay and scientific press about the potential of COX-2 inhibitors as anti-inflammatory and analgesic agents that lack the gastrointestinal side-effects of traditional NSAIDs. Although research on COX-2 inhibitors has focussed mainly on inflammation… CONTINUE READING
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