Cyclooxygenase-2 inhibitor-associated acute renal failure: case report with rofecoxib and review of the literature.

@article{Morales2002Cyclooxygenase2IA,
  title={Cyclooxygenase-2 inhibitor-associated acute renal failure: case report with rofecoxib and review of the literature.},
  author={Enid Morales and Jeffrey J. Mucksavage},
  journal={Pharmacotherapy},
  year={2002},
  volume={22 10},
  pages={1317-21}
}
Cyclooxygenase (COX)-2 inhibitors are widely prescribed for their antiinflammatory and analgesic effects. The potential for COX-2 inhibitors to exert deleterious effects on renal function similar to those of traditional nonsteroidal antiinflammatory drugs is not well defined. Until recently, COX-1 was considered responsible for the synthesis of renal prostaglandins. However, COX-2 is also constitutively expressed in the human kidney Clinical studies have reported a significant decrease in… CONTINUE READING

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